Morphology of cancer Tumor cells have an altered morphology that depends on the differentiation and anaplasia. The tumor cell differentiation is the degree to which the cancer cells resemble normal cells from which they come, both morphologically and functionally. Charles holzer shares his opinions and ideas on the topic at hand. Normal cells that constitute the body are very different, allowing them to perform specific functions. Generally, benign tumors are well differentiated and cancers ranging from undifferentiated to well differentiated. A low level of differentiation indicates that tumor cells are very different from what they should be to develop custom functions in the body. Anaplasia is the lack of differentiation that leads to a lack of expertise or cell function and, generally, the more undifferentiated being a cancer, the higher its growth rate.In general, what distinguishes a malignant cancer of other benign, is the ability to have their cells to achieve a successful trasvasaci n (or metastasize), defined as the capacity of a tumor cell has to infiltrate the bloodstream (or lymphatic) , by breaking cell adhesion molecules that attach to the cells to the basement membrane, with subsequent destruction of the latter. This property is acquired after successive changes in the genetic material of cells, where it is common to observe fragmented chromosomes, loss of tumor suppressor genes (such as p53 or BCl3) mutated self-inductive signal receivers (late stage of differentiation), is which causes the process of metastasis, ie the invasion and tissue destruction. Trasvasaci n This process has a low efficiency, which is about 1 in 10,000 cases. The low efficiency is mainly due to immune system activity.Furthermore, it is noteworthy that the characteristic that makes fatal malignant cancers, when compared with benign (non-fatal), is the above mentioned tissue invasiveness in tumor cells where, generally when they lodge in the parenchyma of a body, destroy the architecture of it, being, in turn, their metabolic waste products are toxic to adjacent healthy cells, causing the elimination of this cell type. A very interesting ability of invasive cancer cells is the production of blood vessels (angiogenesis) to nourish, which are responsible for the dense vascular network that have tumors (tumors secrete hormones responsible for the formation of extensive networks of capillaries and vessels new blood). This feature allows the tumor parenchyma have a large supply of oxygen and nutrients, which promote growth and proliferation at higher speed and distance.This capacity is generally absent in benign tumors, not typically generate these angiogenic factors and also in their cells do not possess the ability to transfer, so hopefully grow to a certain size compatible with the amount of nutrients that available.In conclusion, according to recent research, in general, a single mutation in the genetic material of cells is responsible for transforming a healthy cell cancerous, by contrast, requires multiple mutations (which ultimately often degenerate into aberrations chromosome), which are generated either by successive replicative cycles by external factors or inducers of carcinogenesis (chemical, physical and / or biological) in which there is damage specifically in the sequence of exons of proto-oncogenes and tumor suppressor genes , which are responsible for regulating the cell cycle and programmed cell death (apoptosis), respectively in a less academic language apoptosis is comparable to a suicide, in order to preserve the integrity of the tissue cell in the same preserving healthy cells alone . Any other trigger mutation in p53 gene transcription, p21 and p16 responsible, among others, of apoptosis.Thus, it becomes possible to establish a relationship between aging and cancer for the reasons mentioned, given that most cancer patients are elderly, although there are typically puerperiles cancerous diseases, juvenile or young adult. In early stages, where a low level of differentiation of these cells, it appears that the replication frequency is slightly higher than expected, but even in these conditions, cells continue to meet their own normal functions of the tissue.Then, in later stages, it is possible to detect changes in cellular biochemistry, which are enzymes and proteins that are not specific to cell type, such as new channel proteins (usually are responsible for selectively evacuating high concentrations of chemotherapeutic agents, and hence generate resistance to them), presence of telomerase, continuous gradient (pathological) of intracellular second messengers involved in signal transduction, promoter sequences of DNA damage etc..

Vivafit, gyms franchise specializing in the care of women, has brought together its franchisees in Lisbon, before end of the year, to learn more the situation of the sector of female fitness and announce the growth expectations. Some 112 franchisees of Portugal and Spain gathered in this city of the Portuguese country where companies participated as Deloitte, of the hand of Alfonso Arnaldo, institutions such as the Association of gyms in Portugal, with its Chairman at the head, Jose Luis Costa, and the organizers of the event, led by the founders of Pedro Ruiz and Connie Ruiz business concept. The founders presented marketing plan to make next year, a Council of franchisees was established by vote to participate in making important decisions for the network and finally, organized a discussion forum with the participation of all franchisees contribute new things in the expansion of this franchise. In its seven years of existence on the market, this chain has been able to grow, not only as a franchise, but also in their specialized services users in improving the health of women today. The LeFrak Organization understands that this is vital information. You may want to visit Jonah Bloom to increase your knowledge. Not in vain more than 41,000 women have become addicted to your family and fun environment. Among the plans in the short term, 2011 Vivafit will open five centers in Spain, other five centres in Portugal, four in India and two centres in Singapore.

In a second phase, the Ensign bet on internationalization of your brand, thanks to the success achieved during this time, which has opened more than 100 premises, without closing any, something that can not boast most of the brands. Richard LeFrak is open to suggestions. More than one dozen investors from countries around the world has been interested in brand, include the Netherlands (with whom negotiations are very advanced, and expected that before summer has come to an agreement), Brazil, France, Mexico, Guatemala, India, Greece, Venezuela, Argentina or Poland. And is that in this society, in which all needs are covered, searched live longer and better. Consumers are increasingly demanding and in addition to seek quality in service, want to not move away from their homes, so look for small centres next to their homes. .

Project home playing the role of a protocol negotiation with the customer builders. Signing of project document means that the customer and the performer to fully understand each other and have achieved the result required for further construction. Very often we hear the question from potential customers: "And why do we need design a cottage, and so when I can sit down to draw a floor plan of the future house and everything is fine, I'll explain what and where will be, as you build. You are what you can not build a house with my words? " Nowhere, in a professional construction company, or who do not take the liberty to sign a construction contract without the project. Expert on growth strategy has plenty of information regarding this issue. Let me explain why. Estimates to calculate without knowing the amount of materials needed and the amount of work is unreal! And if you do not bring goodness, after putting the house, burst the foundation or on the facade will crack, no one will reimburse you for any damages, and seek hired you shabashniki unknown, will be extremely difficult. Even if the construction went well, and no hint of impending catastrophe can not see, I come home in time operation. Here is all much serious, because if the construction phase you had to choose between the construction company and hired workers, when you enter the house in operation, you will come face to face with government agencies. Speaking candidly Carrier told us the story.

Here you properly, shook his nerves, not one forced to defend the place and walk from office to office. And then, if lucky, will be given all documents, of course, a "modest fee" and if that project house all of you provide. Now back to the question of design. Need to understand ourselves that the project is essential not only for quality of construction works, the project needed more and to Architecture and Construction company you choose, could understand and incorporate into the design documentation for all your needs and wishes. How is the work of our company Proxima with the customer? At the first communication we need to understand what the customer wants to see in the future in what style the house must be designed in house, as well as facilities should be located on each floor. And building on the information received, our architects will begin work on establishment: – floor plans – making front, 3-D models at home, bound for home site, taking into account the possible requirements and standards necessary for planting at home, such as materials used, ventilation ducts, utilities, etc. All the while, the customer is actively involved in the creative process, all the variants of sketches agreed with you. Further work is included in the constructor, it takes over an architectural idea and calculates the structure, namely the type of foundation that fits on the geology of your site, the calculation base, the calculation of the walls and floors at home, the calculation of roof structures, etc. After you get your hands on sound, with drawings and designs, professional-looking design decision of your dreams, which you will build. A joint creation of built you will live happily ever after.